Archive for October, 2008

Colon Cancer Drug Won’t Help Those With Certain Gene Mutation

Thursday, October 23rd, 2008

A new study suggests that people with advanced colon cancer who have a particular gene mutation won’t benefit from the medication cetuximab (Erbitux).

While the drug can add months to the lives of people without a mutation in a gene called K-ras, those who have the mutation won’t see any benefit from this additional therapy, reports the study, which is published in the Oct. 23 issue of the New England Journal of Medicine.

“We believe that, in the context of pre-treated advanced bowel cancer, the K-ras mutation status of the cancer should be determined before using cetuximab, and cetuximab should only be given to patients with tumors that do not have the mutation,” said study author Dr. Christos S. Karapetis, a senior consultant medical oncologist and director of clinical research in the department of medical oncology at Flinders Medical Centre in Australia.

Karapetis said that about four in 10 people with colon cancer have the K-ras mutation.

Erbitux works by interrupting cell growth and division. It does this by binding to a receptor known as epidermal growth factor receptor (EGFR). A mutation in the K-ras gene is believed to interfere with cetuximab’s ability to disrupt EGFR, according to the study.

For the study, 572 people with advanced colorectal cancer were randomly assigned to receive either weekly treatment with cetuximab and supportive care (287 people) or supportive care alone (285 people). All had undergone other treatment options without success.

Almost 400 tumor specimens from the study volunteers were tested for K-ras mutations (198 from the cetuximab group and 196 from the supportive care group). Just over 42 percent of the tumors evaluated were found to have mutations in the K-ras gene.

Even with cetuximab treatment, people with K-ras mutations had no significant changes in overall survival or in progression-free survival. Those without the mutations, on the other hand, appeared to benefit significantly from the therapy.

People with no K-ras mutations who were treated with cetuximab had nearly twice the overall survival rate compared to the supportive care group — 9.5 months versus 4.8 months. And, the time of progression-free survival was also nearly doubled for those treated with cetuximab — 3.7 months versus 1.9 months in the supportive care group.

“Patients with a colorectal tumor bearing mutated K-ras did not benefit from cetuximab,” the researchers concluded.

“This study suggests that if someone has this particular mutation, they won’t respond to this drug,” said Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society. “The bottom line is that this study is important and really has the potential to impact how we treat patients with colorectal cancer with this very expensive drug.”

He added that other researchers have noted similar results for K-ras mutations in earlier-stage colorectal cancer.

“This is one more refinement on personalized medicine, and we’re moving into an age of molecular markers that eventually will guide treatment. If someone has a cancer in the future, that cancer will be analyzed for what kind of cancer it is, and then we’ll know what the best treatments are for that cancer,” Lichtenfeld said.

Another important molecular marker that guides treatment is already in use for breast cancer treatment, according to Lichtenfeld. Breast cancers are tested for HER2, a type of estrogen and progesterone receptor. Those with this molecular marker are likely to have a more aggressive type cancer, but also a type of cancer that responds to treatment with the drug trastuzumab (Herceptin).

“I’m excited about the future, and this study shows we can be more targeted with our targeted therapies,” said Lichtenfeld.

In India, across the world, people stand up for a cause

Thursday, October 23rd, 2008

More than 700 villagers of Badarpur Khadar village near Delhi joined millions across the world to stand up for a global cause urging governments across the world to meet the UN’s Millennium Development Goals (MDGs) by 2015.

With no electricity, clean drinking water, sanitation or other health facilities, the villagers participated in the campaign with vigour as they opened the village’s first school in its 300-year history Oct 18.

“As compared to other places, there is nothing much in our village. But I am happy that we have a school now. I go to the school and hope that someday my village will be as developed as the city,” said seven-year-old Irfana, a resident of the village.

More than 116 million people, which includes 14 million in India alone, in a gesture to tell various countries’ governments that the MDGs have to be met by 2015 and that extreme poverty has to be ended, participated in the ‘Stand up, Take Action’ campaign against poverty making into the Guinness Book of World Records.

“Over three days time, from Oct 17-19, two percent of the world population, which includes 14 million in India took part in the Stand up, Take Action campaign to urge governments to meet the MDGs by 2015. A record recognised by the Guinness Book of World Records,” Minar Pimple, deputy director Asia, United Nations Millennium Campaign, said at a conference in the capital Wednesday.

In 2000, leaders of 189 countries signed the UN’s Millenium Declaration agreeing to do everything in their power to end poverty. They pledged to do this by achieving the MDGs, a roadmap to end extreme poverty by 2015. The Stand up campaign is a reminder to the world leaders about the same.

Among the eight MDGs are eradication of poverty and hunger, achievemnt of universal primary education, promotion of gender equality, reduction of child mortality, improvement of maternal health, combatting HIV/Malaria and other diseases, ensuring environmental sustainability and developing a global partnership for development.

Sachin’s milestone inspiring: Sania

Wednesday, October 22nd, 2008

Sania Mirza might be a renowned name in women’s tennis but it’s cricket that sets her pulse racing. Therefore it comes as no surprise when she exults at India’s historic win over Australia and finds Sachin Tendulkar’s milestone of becoming the leading Test scorer inspiring.

Sania, who is here for the treatment of her chronic wrist injury, said she thoroughly enjoyed India’s 320-run record win at Mohali Tuesday.

‘Cricket has been my first love. It was great to see India winning over the best team in the world with such a big margin,’ said the Hyderabadi, who has been practising at the Delhi Lawn Tennis Association (DLTA).

Asked how she felt when her favourite cricketer Sachin bested West Indian Brian Lara’s record she said: ‘It is very inspiring, not only for myself but for every cricket follower. Sachin is one of the best cricketer of the world, so it is a proud moment for everyone. I messaged to congratulate him.’

The 21-year-old says she is recovering well from her wrist injury.

‘It has been tough mentally for me. It was painful not to play at the U.S. open as I have always done well there. But I am a person who likes to take positives from every situation. But I have not set a date for myself to return on the circuit.’

‘Hopefully, I should be back for the Hong Kong event,’ Sania said who will be flying back to Hyderabad Thursday.

Delhi hospital fined Rs.500,000 for negligence

Wednesday, October 22nd, 2008

A consumer court has asked a leading government-run hospital here to pay Rs.500,000 in compensation to the widow of a man who underwent incorrect radiotherapy as a result of which he died.

“Taking an overall view of the matter, we find the hospital alone guilty for deficiency in service and in our view a lumpsum compensation of Rs. 500,000 shall meet the ends of justice,” Justice J.D. Kapoor, president of the Delhi Consumer Disputes Redressal Commission said in his order.

The ruling came on an appeal of the Lok Nayak Jai Prakash (LNJP) Hospital against an order of the district consumer commission asking it to pay Rs.800,000 in compensation.

Ramveer Singh had been admitted to the G.B. Pant Hospital here Dec 16, 1997 and was operated upon Dec 19 for removing a tumor. He was discharged Dec 26.

However, he suffered a relapse and was again admitted to the hospital April 25, 1998, was operated upon May 1 and was discharged a week later.

Singh was then referred to the LNJP Hospital for radiotherapy for removing tumor tissues that had developed in his body. The treatment commenced May 25.

Singh underwent two sessions of radiotherapy. In the first, lead blocks were placed around the affected area of the spinal cord but in the second, but in the second, wet cotton gauze was used instead. This resulted in Singh being paralysed from the waist downwards. He ultimately died Oct 20, 2004.

Singh had first approached the district consumer forum, alleging that the LNJP doctor who conducted the radiotherapy was a trainee and did not check the focus of the heat on the affected portion of his body, thus causing his paralysis.

The district forum awarded Singh’s widow Rs.800,000 but the LNJP Hospital contested this, saying there had been no medical negligence on its part. No complications had occurred due to any error in conducting the radiotherapy, the hospital said in its appeal to the state consumer commission.

In his order, Kapoor said: “Whenever a patient lands himself in a hospital, private or government, his direct contract is with the hospital and not with the attending staff or the doctors as there is no consideration paid to those doctors or staff individually.”

He further noted the direct relationship was between the patient and the hospital. Therefore, no individual doctor can be held liable.

“The consumer does not avail services of such doctors individually by paying fees or consideration to those doctors directly. It is only those persons whose services are hired or availed that come within the net of a service provider,” the commission ruled.

Sex Partners Get STD Alerts by E-mail

Wednesday, October 22nd, 2008

Letting someone you’ve slept with know that you have inadvertently exposed them to a sexually transmitted disease can now be done with the click of a computer mouse.

A new report says 30,000 people have used an Internet service that allows them to alert their sex partners that they may have been infected with syphilis, gonorrhea, HIV or other diseases.

“This has been an innovative and effective way for us to enable people to communicate with their sex partners,” said Dr. Jeffrey Klausner, director of STD prevention and control services at the San Francisco Department of Health.

The inSPOT service, which was created in San Francisco in 2004, is now in place in several states, including Idaho, Louisiana, New York, Oregon, Pennsylvania and Washington, among others. According to the report, the service “has the potential to be a national and international resource.”

“We know inSPOT works,” Klausner said. “I see patients, they come in and say they’ve been notified [about having an STD], and their contact is through inSPOT.”

Typically, health departments in the United States only notify the sexual partners of people with STDs if they might be infected with syphilis, Klausner said. Officials don’t try to track down the partners of people with HIV, the virus that causes AIDS, or diseases such as gonorrhea and chlamydia, he said.

The San Francisco Department of Public Health and a non-profit group surveyed gay men in 2004 and found that most didn’t notify casual sex partners when they were diagnosed with an STD. But the report said men “overwhelmingly said that if there were an easy, convenient and anonymous way to inform their partners of their potential disease exposure, they would use it.”

And so the inSPOT service was born, first as a service for gay men and then for anyone. Users visit a Web site and click through a form that allows them to submit the e-mail address of a sex partner and specify what disease or diseases the person may have been exposed to.

The person potentially exposed to an STD will then get an e-mail with the subject line, “E-card from a concerned friend re: your health via inSPOT.”

People who send the messages can choose to be anonymous or include their name. They also get to choose images to appear on the e-cards, including a photo of the words “I’m so sorry” on a piece of paper.

“We’re living in a new world of Internet communication,” Klausner said. “Most people are online every day. This Internet communication tool affords people a way to send a message anonymously.”

According to the new report, published in the October issue of PLoS Medicine, 15 percent of the e-cards in 2006 and 2007 warned recipients of gonorrhea infection. The percentages for other diseases were 15 percent for syphilis, 9 percent for HIV and 12 percent for chlamydia. Almost half of the cards warned of other diseases, including “crabs” and hepatitis.

Since 2004, 30,000 people have sent nearly 50,000 e-cards, the report said.

It’s possible for people to use the messages to harass or frighten other people. There’s no way to confirm that those who receive messages are actually in danger of infection. Still, there’s little indication that people have abused the system, at least in San Francisco, Klausner said.

“I’ve probably gotten four e-mails from people who have been upset because they think they shouldn’t have gotten this card, someone misused it,” Klausner said. “They couldn’t believe something this serious could so easily have the potential for misuse.”

It’s not clear if the notification service actually helps reduce sexually transmitted disease.

“The real test of this or any approach, including the traditional ones, is their effect on transmission,” said Dr. Richard Rothenberg, a professor at Georgia State University’s Institute of Public Health, who studies partner notification.

However, it may be difficult, if not impossible, to study the impact on health because the service is confidential, Rothenberg said. “I think we, and the authors, must be content with the idea that this appears to be an acceptable method to fulfill the moral imperative of notification, and it has a chance to be a better approach than what we currently do,” he said.

Community sport flourishes during Great Depression

Tuesday, October 21st, 2008

In the year after the 1929 Wall Street crash, Babe Ruth negotiated an $80,000 salary with the New York Yankees.

According to contemporary reports, the nation’s greatest baseball player was asked why he should be paid $5,000 more than President Herbert Hoover. “Why not?” said Ruth. “I had a better year than he did.”

Three years later, Ruth’s salary had been slashed to less than half as the Great Depression gripped the western world and U.S. professional sport, in particular, suffered.

Ruth’s prodigious appetite for home runs and the good things of life mirrored the heady extravagances of the 1920s, a decade highlighted by the 1927 world heavyweight rematch between Jack Dempsey and Gene Tunney.

Tunney retained his title and pocketed a million dollars for half an hour’s work.

Five years the bubble had burst. Thirteen million Americans, more than a quarter of the work force, were out of work, boxing was in a slump and baseball and football attendances had plummeted precipitously.

Under Connie Mack, the Philadelphia Athletics won the World Series in 1929 and 1930 but with large salaries to pay and falling gates, Mack was forced to sell his best players and his team were never a force again before World War Two.

Yet, largely through necessity, the 1930s was the decade when sport became both mass entertainment and recreation in the United States, Europe and the British Empire.

Sport was an inexpensive hobby and soccer, swimming, athletics, boating and camping became popular. The nordic countries practised winter sports, the French cycled and the Germans specialised in gymnastics.

SALARY CAP

European professionals had not enjoyed the giddy salaries paid to their American counterparts who, not for the last time, measured their worth by the sums commanded by their Hollywood contemporaries.

English soccer players taking part in the continent’s most popular sport had their wages capped at eight pounds a week throughout the decade. Tickets remained affordable and grounds were packed.

“The Saturday match became more than mere diversion from the daily grind because there was often no work to be relieved,” wrote Arthur Hopcraft in his 1968 classic “The Football Man”.

“The footballer as representative had become the true working class hero. He came from these streets where the spectators lived.”

Englishman Stanley Matthews was one such working class hero, starting a career at Stoke City in 1932 which was to stretch 33 years.

Another was Australia’s Don Bradman, a self-taught cricketer from the country who became the finest batsman of all time and gave a new country a sense of pride as he led them to victory over their imperial masters.

NEW DEAL

Hoover had declined to open the 1930 Lake Placid Winter Olympics and in his absence his Democratic presidential opponent Franklin Roosevelt grasped the opportunity.

Hollywood helped promote the 1932 Los Angeles Olympics through Douglas Fairbanks, Mary Pickford, Charlie Chaplin, Clara Bow and Marlene Dietrich.

Sixty-nine Brazilians set off in a cargo ship laden with coffee to sell on the way, but in a time of surplus managed to offload enough only to fund 24 of their athletes.

After his election in the same year, Roosevelt’s New Deal helped to spread sport throughout the community.

Organised games and sports were encouraged with gymnasiums, swimming pools, tennis courts and golf courses built as well as dams, bridges, highways and public buildings.

Government and private enterprise combined in 1932 to build the Cleveland Municipal Stadium. Its 80,000 capacity was easily the biggest in the United States.

Britain and France established colleges to train physical education teachers and Portugal introduced compulsory physical education in schools.

Fascist Italy and Germany also encouraged sport, with explicitly militaristic goals, and the Soviet Union All-Union Physical Culture Council was set up to promote mass participation sport.

Two remarkable Americans furthered the cause of black athletes in the face of prejudice at home and abroad as the world emerged from depression and lurched towards war.

Joe Louis fought his way out of Detroit via the Golden Gloves amateur tournaments to become world heavyweight champion.

Jesse Owens, a grandson of slaves, outraged the Nazi propagandists who sneered at the United States for selecting “black auxiliaries” by winning four gold medals at the 1936 Berlin Olympics.

Latest space tourist gets his money’s worth

Tuesday, October 21st, 2008

The world’s latest space tourist, a computer game wizard and astronaut’s son who paid $30 million to fly to the space station, said Monday from orbit that he’s gotten his money’s worth.

With his 12-day adventure winding down this week, Richard Garriott said he felt fulfilled even before he rocketed away on a Russian Soyuz spacecraft on Oct. 12, thanks to all the training he got with astronauts and other space professionals.

“Of course, it’s been great icing on the cake to actually take the rocket ride, which was very exciting, and, of course, the view from up here is spectacular,” he told reporters in a news conference.

Garriott said it’s been especially gratifying speaking from space with his father, retired astronaut Owen Garriott, 77, who flew on NASA’s first space station, Skylab, in 1973. The younger Garriott is the first American to follow a parent into space.

The two have chatted several times each day by radio hookup arranged by Russian Mission Control outside Moscow. Their next conversation will be face-to-face at the Soyuz landing site in Kazakhstan on Friday.

“That’s been a real joy, not just talking to him here from space, but this whole year we’ve actually spent working together for this flight,” said the 47-year-old Garriott. “It’s been a great opportunity for us to bond, so to speak, as adults in ways that we haven’t had a chance to do in many years.”

Garriott, who lives in Austin, Texas, and goes by the gaming moniker “Lord British,” is the creator of the Ultima computer game series. His most recent business with brother Robert, Destination Games, merged with a South Korean gaming giant, NCsoft. Garriott is an executive producer of the American branch, NCsoft Austin.

Back at NASA’s Florida launching site, meanwhile, attention was focused Monday on a mission that has been delayed. Space shuttle Atlantis was hauled off the launch pad and sent back to the hangar to wait until at least February for a trip to the Hubble Space Telescope.

Atlantis was originally scheduled to blast off this month on a mission to make various repairs and upgrade the telescope. But the Hubble broke down three weeks ago and stopped sending pictures, forcing NASA to figure out what went wrong and delay its mission until next year.

Now astronauts will need time to train for a new telescope repair they hadn’t planned on.

Shuttle Endeavour, now at the front of the flight lineup, will be moved from its launch pad to Atlantis’ spot this weekend. Endeavour had been poised to blast off as a rescue ship for Atlantis’ crew if there was an emergency during the Hubble mission. Instead, Endeavour will carry seven astronauts to the space station on an equipment delivery mission; launch is targeted for Nov. 14.

That trip will enable NASA to double the number of astronauts living at the orbiting outpost, from three to six. That transition should occur next spring.

Space station astronaut Gregory Chamitoff said Monday it feels “very productive” to have double the number on board. He’d been living with two Russian cosmonauts since the beginning of June and welcomed the arrival of three new faces one week ago. Later this week, those two cosmonauts and Garriott will return to Earth and leave Chamitoff, fellow NASA astronaut Michael Fincke and Russian Yuri Lonchakov behind in orbit.

“We’ve gone for 4 1/2 months, the three of us, and it’s very exciting to have a full complement up here,” said Chamitoff, who will come home aboard Endeavour.

The 18-year-old Hubble, meanwhile, has been unable to send back pictures of the cosmos since Sept. 27. Flight controllers tried unsuccessfully to get a backup system working last week, and may make another attempt later this week.

When they do fly, the Hubble repair crew members will take up a replacement part for the disabled system.

Chinese exporters look to domestic market

Tuesday, October 21st, 2008

Oct 20 (Xinhua) Chinese exporters, faced with falling foreign orders amid global economic slowdown, are diverting their attention to domestic markets.

Qiao Guan, board chairman of the Jiangsu Hotwind Sauna Equipment, said his company is planning to divert some of the business from abroad to the domestic market.

The company’s sales in the United States, which accounted for about 30 percent of its total exports, had dropped by more than 20 percent this year, Qiao said.

He hoped the local sales could compensate the decreasing orders in the foreign market.

‘We have completed research on the domestic market, which shows some exported goods are affordable and have good sales prospects in the local market,’ he said.

The Himin Solar Energy Group, based in east China’s Shandong province, produces solar water heaters that are sold both at home and abroad. Xue Xinwen, head of the firm’s international trade department, said the company had been losing orders as some Western countries cancelled subsidies on environment-friendly imports.

‘We have sent more staff to market our products to local infrastructure authorities and companies,’ he said.

‘Domestic consumption has been greatly boosted by a robustly growing economy, creating positive situations for exporters to go local,’ he said.

But the readjustment can be difficult.

Li Jianlan, a worker with Wanji Plumbing Materials Co. Ltd, based in Ningbo, said an exclusive exporter like her company lacked channels and brand loyalty in the domestic market.

‘These are two different kinds of markets, and it takes a lot of work to be familiar with the ways business is done with local buyers,’ she said.

Some goods that are made for export are deemed too expensive for Chinese buyers.

Huang Yan, general manager of the L-bright Export Manufacture Corporation, said it had been very difficult to sell its products to domestic buyers as they lacked a price advantage.

Local governments, aware of the trend, are taking action to encourage the conversions. Guangdong province, the country’s major exporting base, issued a notice in June, ordering local quality inspection authorities to provide needed technical assistance to exporters.

Gujarat Industries Power to set up two more units

Tuesday, October 21st, 2008

Vadodara-based Gujarat Industries Power Co Ltd (GIPC) will set up two more lignite-based thermal power projects, each with 250 MW capacity, taking its total power generation capacity to 1,000 MW, a top official said.

The project includes development of a captive lignite mine, said S.L. Bose, GIPC executive director, responsible for the execution of lignite-based thermal power projects.

The power stations are expected to come up at a site close to the existing Surat Lignite Power Plant (SLPP) at Nani Naroli, in Surat district.

Bose told IANS that it was not yet decided whether the project should be undertaken under international competitive bidding or through negotiations. GIPC board would take a call on the issue within four months.

The official refused to divulge investment details, but according to power experts, the total investment would be around Rs.20 billion.

GIPC first set up a combined cycle 165 MW gas power station in Vadodara. Later it executed two lignite-based power stations near Surat with an installed generating capacity of 125 MW each.

The new captive mine being developed for the expansion project has been located at Mangrol near Surat. The mine is designed to produce 2.4 million tonnes of lignite per year.

The engineering procurement and construction (EPC) contract for the expansion project has been awarded to Bharat Heavy Electricals Ltd (BHEL) at a cost of Rs.12 billion. The project is expected to start commercial operation next year.

Microsoft exec touts mixed source ventures

Monday, October 20th, 2008

Microsoft has been making moves on the licensing front and accommodations with open source, such as its controversial 2006 agreement with Novell pertaining to Suse Linux. Looking to elaborate on Microsoft’s activities, Horacio Gutierrez, Microsoft vice president and deputy general counsel for Intellectual Property and Licensing, met last week with InfoWorld Editor at Large Paul Krill at InfoWorld offices in San Francisco. Companies today, Gutierrez said, have become “mixed source” ventures rather than the world being divided up between open source and proprietary.

InfoWorld: What’s happening as far as licensing at Microsoft?
Gutierrez: A lot is happening. This December we will celebrate the fifth anniversary of a significant shift in Microsoft’s approach to licensing. In December of 2003 we changed our patent licensing policy to declare that Microsoft was open for business. That is, Microsoft would be willing to license any of its patents to any third party, including competitors, on commercially reasonable terms. That was a significant shift at that time, but over the last five years we’ve actually been able to see in practice the benefits of that shift. For example, we’ve signed over 500 licensing agreements in the last five years, from very broad patent cross-license agreements with some of the biggest companies in the technology world to very focused outbound technology licenses to startup companies in China or Europe or the U.S., taking advantage of some of the innovations coming out of the research labs. So [we have] quite a significant track record of licensing, especially if you take into account the kinds of relationships and collaborations that weve been able to do on the basis of those IP licensing deals.

InfoWorld: So it was a shift in licensing. What was the before and after?
Gutierrez: The before I think was and continues to be that most companies look at their IP portfolio as an asset that they want to hoard. That plays a very protective role or that springs into action for defensive purposes when they get sued. We choose to look at our portfolio as a tool that we use in order to help bring about the business objectives that the company has. We’ve learned over the last five years that using the portfolio to enable deep interoperability collaboration discussions, for example, is one of the clearest ways in which we can bring value and we’ve had a whole range of successes in that area. I think the most significant one, and perhaps the most surprising one to most people, is the track record in our collaboration with Novell where we’ve created an interoperability laboratory in Cambridge, Mass. We’ve expanded even our collaboration beyond what the original scope of the collaboration was by adding collaborations in accessibility, interoperability technologies, document format, interoperability, the Moonlight plug-in [for] Silverlight for the Linux platform, and a number of other collaborations.

InfoWorld: There has been a lot of criticism and discontent with that agreement in the open source community. One of the expressions I heard was it was a tax on Linux by Microsoft. How do you respond to that?
Gutierrez: Well, it is hard to envision that an agreement in which two industry leaders agree to set their differences aside and collaborate could be viewed as divisive, but be that as it may, it’s been almost two years to the day since we signed that agreement and I think the world has significantly changed since then. In part, because of that and other collaborations that Microsoft has undertaken, but I think fundamentally because the market realities continue to change. For example, it is harder and harder to continue to define the world of software as a world divided between open source companies and proprietary companies. The truth is that today we’re all mixed source companies. Every company that traditionally comes from an open source background has over time moved to the middle after realizing that in addition to the open source foundation, they also need proprietary offerings that will differentiate their services from others and therefore will enable them to build a viable business.

InfoWorld: Who are you referring to there??? Novell?
Gutierrez: No, I’m referring to all of them. If you look at Red Hat, it certainly has a very credible Linux offering.?? At the same time, they admittedly are counting on JBoss and a number of other technologies in order to build a differentiating value proposition and each and every one of them would be that. So at the same time, companies that you could have associated traditionally with a pure proprietary software development model, including Microsoft, you see them today cooperating with open source development projects, even shipping open source code as part of their breadth of their offerings. Over time this distinction, which was mostly an ideological and very emotional distinction, the reality of business is causing all companies to converge to the point where, as I said, in a few years this distinction will be without meaning and we will all be mixed source companies.

InfoWorld: It was a couple of years ago that Steve Ballmer said Linux infringed on Microsoft patents. Has Microsoft ever divulged those patents and does it plan to do that?
Gutierrez: We start by saying that the fact that certain products might infringe on Microsoft patents is not really that interesting. Any company that has a significant portfolio would be able to say that about many products, whether they’re open source or proprietary.?? What is significant here is that these are issues that can and are being solved through the mechanism of licensing. That is when my work and the work of the IP licensing team at Microsoft comes in, by turning those situations into potential collaborations that really answer what customers want. Customers don’t want to have to deal with these issues of interoperability and IP assurance concerns. They want their vendors to come together and solve it and that is the solution that we feel has worked and will continue to work in the future.

InfoWorld: So you’re not going to tell me what those patents were today?
Gutierrez: No, I will say this: Microsoft publishes every patent that Microsoft gets issued and we have had deeper, detailed discussions in the context of private licensing conversations, which by the way is the practice that every technology company follows. So to answer your question, yes, we have divulged them. We have talked about them with a number of companies that have shown interest in having a good faith licensing discussion with Microsoft.

InfoWorld: Can you tell me what one or two of them were?
Gutierrez: I can tell you that there have been a number of them and no, those conversations are business conversations that we tend not to divulge.

InfoWorld: I think it was early this year that Microsoft released documentation on multiple technologies. What’s been the impact of that?
Gutierrez: Well I think it’s been very significant. So far over 44,000 pages of detailed technical specifications have been made available over the Internet for anybody who wants to use them. I think that is an unprecedented step that no other company in the industry has really taken. In addition to that, there are a number of the patents on those technologies that are part of patent maps that we’ve made public and Microsoft has committed to make those patents available for licensing at very low royalty rates.?? So that was one of the commitments that Microsoft made back in January in the context of the interoperability principle, but there were also a number of other principles included in there.?? For example, [that] deal with data portability, that deal with Microsoft support of industry standards, and that deal with the kind of industry consultation mechanisms that are really necessary to be able to advance the ball in that area.

InfoWorld: I was speaking with the executive director of the Eclipse Foundation the other day, Mike Milinkovich, and we talked a little bit about whether Microsoft was ever going to join Eclipse. Is Microsoft going to do that?
Gutierrez: Well actually, I think it must have been 48 hours ago that they actually commended Microsoft for having explicitly agreed to contribute in a number of areas. I am really not the right person to talk technically about the scope of the collaboration.??

InfoWorld: But is Microsoft going to join the foundation?
Gutierrez: I really wouldn’t be able to answer. I’ll tell you, we have now a breadth and depth of engagement with the open source community and a number of key development projects that is really unprecedented in the history of the company.

InfoWorld: So you’re working with Eclipse and Apache and I think there might have been another organization?
Gutierrez: That’s right, a number of them.?? And I think you would find, in this area, that [Microsoft executive] Sam Ramji would be a much more adequate spokesperson.

InfoWorld: Is Microsoft going to offer any more products under open source? Has Microsoft looked at the GNU license or anything like that?
Gutierrez: I am sure that you’re going to see a lot more from us, both in terms of the kinds of licensing programs that we create as well as the kinds of things that we’re going to be able to do in our collaboration with open source. So in general I would say the answer to your question is yes. I think the most significant part of this is that we’ve learned over the last five years, having done over 500 licensing deals, that it is possible to develop a licensing program that really enhances the collaboration opportunities for companies where you get the benefit of the innovation that other companies do and at the same time you’re able to share yours.?? And this open innovation paradigm is one that we see growing and consolidating over the years and we feel that there is a very important role for the licensing work that we do in order to make that possible.

InfoWorld: What do you see as the major issue that end user enterprise customers are facing in terms of licensing?
Gutierrez: The major issue they’re facing is ensuring that they can continue to have a heterogeneous network that has products that have been designed to work well with each other. The reality is that most customers do have a combination of technologies in their installations and they do not wish to rely on a single vendor.?? What that reality poses is the challenge of designing and developing products that work well with each other. IP licensing plays a role in enabling that interoperability work being done.?? The feedback that we received in our collaboration with Novell has been, first of all, very supportive of the deep collaboration that we’re doing, and that has been resulting in tremendous commercial success on the part of Novell in that particular instance. ??For example, they grew over 38 percent between 2006 and 2007 in the Linux market.?? They were the commercial vendor that grew the fastest in that segment.?? Their market share grew almost 10 percent year over year. And this is the result of the appreciation that customers in the enterprise give to the efforts that Microsoft and Novell have put in solving real life, customer-centric, interoperability challenges and providing them with peace of mind from the point of view of intellectual property.?? So there is a model by which these customer objectives can be met.

InfoWorld: Novell is working on a couple of different projects to put the Microsoft technologies on Linux and other platforms. One is the Mono project to put the .Net Framework on Linux and other platforms and the other is Moonlight, offering Silverlight for Linux. Is there anything else coming down the pike from either Novell or other companies that are going to take high-profile Microsoft technologies and enable them to work on Linux or other platforms?
Gutierrez: Yes, the Novell and Microsoft joint interoperability lab, in addition to the areas that you mentioned, are already delivering results in terms of document format interoperability, interoperability between the ODF format and the Microsoft file formats.?? They’re working on a number of accessibility, interoperability solutions.?? They’re working on identity and directory services interoperability.?? They’re working on systems management solution and virtualization. So there’s a whole range of things, the results of which are already apparent in some cases and in other cases you will see become apparent over the next couple of years.

InfoWorld: What about the issue of piracy??? Is that still a problem?
Gutierrez: Piracy is a global problem and I think to be able to assess how we’re doing you would have to really separate by region or even by country. I think there are a number of countries in which we’ve had some encouraging progress and we’ve seen, for example, some positive steps being taken by some of the key governments in the largest jurisdictions. In other countries, piracy continues to be rampant with rates that exceed 90 percent in some cases.?? This is the kind of problem that you’re not going to solve with a uni-dimensional approach. Piracy is a problem that needs to be solved by a combination of things, by enhancing the legal system in order to create the tools that are necessary from a legal perspective to protect intellectual property. Once the laws are in the books then you need to have an enforcement mechanism that focuses on the piracy problem and is technically equipped to detect it and to fight piracy, which in many countries is associated with organized crime. It is really significant business in many countries. You need education from the point of view of the consumer. And then you need a judicial system that understands the IP issues and is prepared to enforce them. So it’s really the whole spectrum of activities that will bring the results and it’s certainly a long-term battle.

InfoWorld: Can you name a country or two where things have gotten better and one or two countries where things are still pretty bad??? And how much money does Microsoft lose through piracy each year?
Gutierrez: We can send you the information from a software industry perspective. I don’t think we’ve put a number specifically on the impact on Microsoft, but it is very clear that piracy costs industry billions of dollars every year and it certainly costs governments significant amounts of money in tax revenue that it doesn’t collect because the piracy is conducted through informal commercial channels.?? I would point out that we’ve been encouraged by some of the steps that the Chinese government has taken in working with industry to try to collaborate. This is clearly not the end of the road and there’s a tremendous amount of work that continues to be done, but certainly we’ve seen over the last two years that this is an issue that’s been taken more seriously.

InfoWorld: What places are still a problem?
Gutierrez: There are a number of countries in Latin America.?? And sadly enough, I would say although the piracy rate is not as high [here] as in other countries, we felt that we could have made a lot more progress in the U.S. itself in dealing with the piracy issue. ??But as I said, it’s a process and it’s a process that will take many years to get to the end.